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New method boosts the study of regulation of gene activity
1 Jul 2022 at 11:31am
Researchers report the development of a chemical-based sequencing method to quantify different epigenetic markers simultaneously. Their method, called NT-seq, short for nitrite treatment followed by next-generation sequencing, is a sequencing method for detecting multiple types of DNA methylation genome-wide.

'Soft' CRISPR may offer a new fix for genetic defects
1 Jul 2022 at 11:31am
Scientists have developed a new CRISPR-based technology that could offer a safer approach to correcting genetic defects. The new 'soft' CRISPR approach makes use of natural DNA repair machinery, providing a foundation for novel gene therapy strategies with the potential to cure a large spectrum of genetic diseases.

When ASD occurs with intellectual disability, a convergent mechanism for two ...
1 Jul 2022 at 10:00am
Scientists have discovered a convergent mechanism that may be responsible for how two top-ranked genetic risk factors for autism spectrum disorder/intellectual disability (ASD/ID) lead to these neurodevelopmental disorders.

New sibling diagnosis for post-traumatic stress disorder
1 Jul 2022 at 8:31am
The World Health Organization (WHO) recently listed a new sibling diagnosis for post-traumatic stress disorder (PTSD), termed complex post-traumatic stress disorder (CPTSD). An international team has now summarized the symptoms of the long-awaited new diagnosis and issued guidelines for clinical assessment and treatment.

Protecting the brain from dementia-inducing abnormal protein aggregates
1 Jul 2022 at 7:27am
Neurodegenerative diseases like Alzheimer's and Parkinson's are defined by pathogenic accumulation of toxic proteins in the brain. Now, however, scientists have established that the p62 protein, which is involved in cellular protein degradation, can prevent the accumulation of toxic oligomeric tau species in mouse brains, proving the 'neuroprotective' function of p62 in a living model.

Adolescents more vulnerable to cannabis addiction but not other mental health...
1 Jul 2022 at 7:27am
Adolescents are over three times more vulnerable to developing a cannabis addiction than adults, but may not be at increased risk of other mental health problems related to the drug, according to a new study.

Scientists warn of links between soil pollution and heart disease
1 Jul 2022 at 7:27am
Pesticides and heavy metals in soil may have detrimental effects on the cardiovascular system, according to a review paper.

HIV speeds up body's aging processes soon after infection, study shows
1 Jul 2022 at 7:27am
HIV has an 'early and substantial' impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection, according to new research.

Plug-and-play test for keeping track of immunity to Sars-CoV-2 variants
1 Jul 2022 at 7:27am
Many antibody tests have been developed since the pandemic started, but very few are designed to specifically detect the Sars-CoV-2 neutralizing antibodies which prevent infection. Based on protein complementation, the modular method described here is the first of its kind to measure neutralizing antibodies against variants, from a drop of blood, in under one hour and at low cost.

Machine-learning algorithms can help health care staff correctly diagnose alc...
1 Jul 2022 at 7:27am
New research finds that machine-learning algorithms can help health care staff distinguish the two conditions. Researchers show how algorithms may be effective predictive tools using a few simple variables and routinely available structured clinical information.

Research reveals structure of a human endogenous reverse transcriptase
30 Jun 2022 at 1:47pm
The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and other diseases, according to a study co-authored by a Rutgers researcher.

Researchers discover new leukemia-killing compounds
30 Jun 2022 at 1:00pm
Researchers have discovered potential new drugs that target mitochondria in cancer cells. Their study in the journal Leukemia describes the compounds' potential for killing leukemia cells when administered by themselves or in combination with other chemotherapies.

Borrowed gene helps maize adapt to high elevations, cold temperatures
30 Jun 2022 at 1:00pm
An important gene in maize called HPC1 modulates certain chemical processes that contribute to flowering time, and has its origins in 'teosinte mexicana,' a precursor to modern-day corn that grows wild in the highlands of Mexico. The findings provide insight into plant evolution and trait selection, and could have implications for corn and other crops' adaptation to low temperatures.

Signaling molecule potently stimulates hair growth
30 Jun 2022 at 11:22am
Researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

Developmentally arrested IVF embryos can be coaxed to divide
30 Jun 2022 at 11:22am
Why do two-thirds of in vitro fertilization (IVF) embryos go into developmental arrest? A new study shows that many embryos stored for IVF undergo characteristic genetic and metabolic changes that inhibit development. These results help explain the loss of developmental ability of many harvested embryos, and may point to strategies for increasing the proportion of developmentally competent embryos.



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