(Health-NewsWire.Net, September 07, 2016 ) Wilson’s disease is a rare disease and is named after Kinnear Wilson who was the first to describe this disorder in 1912. His description terms the disease as a “progressive lenticular degeneration,” a hereditary, fatal neurological disease that is usually accompanied by chronic liver ailment that leads to a condition called cirrhosis. Wilson's disease is a hereditary disorder that leads to unwarranted accumulation of copper in crucial organs such as the liver, brain etc. The patient starts to accumulate copper from birth but diagnosis tends not to occur only in the later ages. The primary signs of Wilson’s disease become prominent usually between the ages of 12 and 23 years.
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Wilson’s disease is caused by the mutation of a gene named ATP7B. Absent or reduced function of ATP7B protein leads to reduced elimination of copper into the bile. Wilson’s disease is inherited as an autosomal recessive trait, which means that in order to develop the disease one must inherit two procreations of the defective gene, one from each parent. If a person receives only one abnormal gene from either of the parents, he/she is not likely to get affected by the Wilson’s disease. Wilson’s disease may be difficult to primarily diagnose as the symptoms are alike to other health issues like heavy metal poisoning, hepatitis C, and cerebral palsy.
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Table of Content
1. Market Overview 1.1 Introduction 1.2 Causes 1.3 Symptoms 1.3.1 Hepatic Symptoms 1.3.2 Neurological Symptoms 1.3.3 Ophthalmic Symptoms 1.3.4 Other Symptoms 1.4 Diagnosis 1.5 Treatment through Medications 1.5.1 D-penicillamine 1.5.2 Trientine 1.5.3 Zinc Salts 1.5.4 Ammonium tetrathiomolybdate 1.5.5 Bis-Choline Tetrathiomolybdate – Decuprate
2. Global Market 2.1 Global Orphan Drugs Market Revenue – Actuals 2.2 Global Orphan Drugs Market Revenue – Forecast 2.3 Wilson’s Disease Prevalence by Region 2.4 Wilson’s Disease Market by Treatment – New Patients 2.5 Wilson’s Disease Market by Treatment – Experienced Patients 2.6 Global Decuprate Revenue – Forecast 2.7 Global Liver Transplantation by Region
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